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Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophagecolonystimulatingfactor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death .
Otilimab (GSK 3196165) is an anti-granulocyte-macrophagecolony-stimulatingfactor (GM-CSF) human monoclonal antibody. Otilimab neutralises the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor .
Magmas-IN-1 (compound 9) is a small molecule Magmas inhibitor (SMMI). Magmas is mitochondria associated，granulocyte-macrophagecolonystimulatingfactor signaling molecule，as well as a GM-CSF inducible gene in myeloid cells. Magmas-IN-1 inhibits Magmas and modulates mitochondrial function. Magmas-IN-1 also inhibits proliferation in yeast at 4 μM .
Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophagecolonystimulatingfactor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death .
Otilimab (GSK 3196165) is an anti-granulocyte-macrophagecolony-stimulatingfactor (GM-CSF) human monoclonal antibody. Otilimab neutralises the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor .
GM-CSF Protein, a renowned cytokine, promotes the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. Operating as a monomer, it interacts with the GM-CSF receptor complex. This complex, comprising two head-to-head hexamers with two alpha, two beta, and two ligand subunits, forms a dodecamer structure. Animal-Free GM-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeGM-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free GM-CSF Protein, Mouse (His) is 124 a.a., with molecular weight of ~15.1 kDa.
GM-CSF Protein, a cytokine, promotes the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. It functions as a monomer, interacting with the GM-CSF receptor complex, forming a dodecamer structure with two alpha, two beta, and two ligand subunits in head-to-head hexamers (By similarity). GM-CSF Protein, Rat (HEK293, His) is the recombinant rat-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM-CSF Protein, Rat (HEK293, His) is 127 a.a., with molecular weight of 17-25 kDa.
The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages, including granulocytes, macrophages, eosinophils, and erythrocytes. Structurally, GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex. GM-CSF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GM-CSF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GM-CSF Protein, Mouse (HEK293, Fc) is 124 a.a., with molecular weight of 45-60 kDa.
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (HEK293, Fc) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GM-CSF Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 48-55 kDa.
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (HEK293) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with tag free. The total length of GM-CSF Protein, Human (HEK293) is 127 a.a., with molecular weight of ~19-25 kDa.
The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages, including granulocytes, macrophages, eosinophils, and erythrocytes. Structurally, GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex. GM-CSF Protein, Mouse (HEK293, His) is the recombinant mouse-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM-CSF Protein, Mouse (HEK293, His) is 124 a.a., with molecular weight of 18-30 kDa.
The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages, including granulocytes, macrophages, eosinophils, and erythrocytes. Structurally, GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex. GM-CSF Protein, Porcine is the recombinant Porcine-derived GM-CSF protein, expressed by E. coli , with tag free. The total length of GM-CSF Protein, Porcine is 127 a.a., with molecular weight of ~17.02 kDa.
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GMP GM-CSF Protein, Human (HEK293, His) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP GM-CSF Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 17-30 kDa.
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (HEK293, His) is the recombinant human-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM-CSF Protein, Human (HEK293, His) is 127 a.a., with molecular weight of 17-30 kDa.
The GM-CSF protein is a key cytokine that fundamentally stimulates the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. As a monomer, GM-CSF interacts with the GM-CSF receptor complex to form a dodecamer, which contains two α, two β, and two head-to-head hexamers of the ligand subunits. GM-CSF Protein, Bovine (P. pastoris, His-Myc) is the recombinant bovine-derived GM-CSF protein, expressed by P. pastoris , with C-Myc, C-6*His labeled tag. The total length of GM-CSF Protein, Bovine (P. pastoris, His-Myc) is 126 a.a., with molecular weight of 18 kDa.
The GM-CSF protein functions as a key cytokine that promotes the growth and differentiation of hematopoietic precursor cells of different lineages, such as granulocytes, macrophages, eosinophils, and erythrocytes. In its monomeric form, GM-CSF acts as a signaling molecule, orchestrating complex receptor assemblies. GM-CSF Protein, Human (P. pastoris, N-His) is the recombinant human-derived GM-CSF protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of GM-CSF Protein, Human (P. pastoris, N-His) is 127 a.a., with molecular weight of 16.5 kDa.
GM-CSF R alpha is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2. GM-CSF R alpha binds to the cytokine with high specificity and low affinity. GM-CSF R alpha binds to GM-CSF and induces cell differentiation. GM-CSF R alpha monoclonal antibody decreases GM-CSFRα expression on GM-CSF-responsive cells and shows anti-inflammatory activity in rheumatoid arthritis (RA). GM-CSF R alpha Protein, Human (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 320 amino acids (M1-G320) and is produced in HEK293 cells.
GM-CSF R alpha is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2. GM-CSF R alpha binds to the cytokine with high specificity and low affinity. GM-CSF R alpha binds to GM-CSF and induces cell differentiation. GM-CSF R alpha monoclonal antibody decreases GM-CSFRα expression on GM-CSF-responsive cells and shows anti-inflammatory activity in rheumatoid arthritis (RA). GM-CSF R alpha Protein, Human (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 298 amino acids (E23-G320) and is produced in HEK293 cells.
The CSF2 protein is a cytokine that plays a critical role in the regulation of immune responses and hematopoiesis. It stimulates the production and differentiation of white blood cells, including macrophages and granulocytes. GM-CSF Protein, Canine is the recombinant canine-derived GM-CSF protein, expressed by E. coli , with tag free. The total length of GM-CSF Protein, Canine is 127 a.a., with molecular weight of ~15.11 kDa.
